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Assessment of the Presence of Pharmaceutical Compounds in Wastewaters and in Aquatic Environment

Valbona Tahiri, Astrit Denaj, Dode Prenga

Abstract


In this work, we have analyzed the presence of pharmaceutical compounds in the wastewater of a regional hospital in Vlora, Albania, during June 2020 and June 2021. For this analysis, we measured the concentration of 19 preselected pharmaceutical molecules in discharging water by direct sampling in the waters, and we investigated the presence of pharmaceuticals in the algae Ulva Lactuca. Chemical analysis has been conducted via liquid chromatography in tandem with mass spectrometry at a limit of quantization of 0.1 ng/L. It resulted that, from the ensemble of 19 pharmaceutical molecules consisting of antibiotics, analgesics, psychiatric drugs, and beta-blockers, the antibiotics were found at the highest concentration. The quantity of medical chemicals’ presence varies from 0.2 to 0.24 mg/L. Traces of pharmaceuticals are obtained from Ulva Lactucaalgae in effluent water next to the city treatment plant. The concentration for each of the 19 molecules considered in this work remains below 0.1 ng/L. Finally, the values of physicochemical parameters were found within the range reported by several studies for hospital influent waters, collected in different countries and for many years.

 

Doi: 10.28991/HEF-2023-04-03-03

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Keywords


Pharmaceutical Residues; Tandem Mass Spectrometry; Water Pollution.

References


Frascaroli, G., Reid, D., Hunter, C., Roberts, J., Helwig, K., Spencer, J., & Escudero, A. (2021). Pharmaceuticals in wastewater treatment plants: A systematic review on the substances of greatest concern responsible for the development of antimicrobial resistance. Applied Sciences (Switzerland), 11(15), 6670. doi:10.3390/app11156670.

Gros, M., Petrović, M., Ginebreda, A., & Barceló, D. (2010). Removal of pharmaceuticals during wastewater treatment and environmental risk assessment using hazard indexes. Environment International, 36(1), 15–26. doi:10.1016/j.envint.2009.09.002.

Roberts, P. H., & Thomas, K. V. (2006). The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment. Science of the Total Environment, 356(1–3), 143–153. doi:10.1016/j.scitotenv.2005.04.031.

UNEP (2023). Addressing pharmaceutical waste in Albania. United Nations Environment Programme, Nairobi, Kenya. Available online: https://www.unep.org/news-and-stories/story/addressing-pharmaceutical-waste-albania (accessed on May 2023).

Interreg (2023). Interreg IPA CBC “Greece-Albania 2021-2027”. Thessaloniki, Greece. Available online: https://greece-albania.eu/projects. (accessed on May 2023).

Dibra, H., & Bushati, N. (2023). Microbial indicators of coastal water in Velipoja beach, Albania. Academic Journal of Business, Administration, Law and Social Sciences, 9(3), 48-53. doi:10.2478/ajbals-2023-0009.

Leonetti, L., Boshnjaku, A., Travlos, I., Antonopoulos, N., Gazoulis, I., & Favilli, F. (2022). SWOT workshop: SWOT analysis of eco-pastoral habitat systems management in the pilot area–Albania/Greece and for Ecological Connectivity Potentials. EU Interreg Adrion DINALPCONNECT Project, 1-56

Tahiri, V., Prenga, D., Denaj, A., & Vullkaj, I. (2019). Assessment of Heavy Metals Content in Vlora Bay Using Atomic Absorption Spectrometry. MATTER: International Journal of Science and Technology, 5(2), 113–122. doi:10.20319/mijst.2019.52.113122.

Denaj, A., Spahiu, D., & Qarri, F. The Determination of Mercury (Hg) In the Soils Collected in The Bay of Vlora. Interdisciplinary Journal of Research and Development, 4(2), 268–275.

Tahiri, V., Denaj, A., Bakaj, A., Vullkaj, I., & Musli, F. (2019). A Study of Physicochemical Parameters and Heavy Metals Concentration Levels in Orikumi Lagoon, Vlora, Albania. MATTER: International Journal of Science and Technology, 5(2), 136–148. doi:10.20319/mijst.2019.52.136148.

Petri, O., Ulqinaku, D., Kika, B., & Abazaj, E. (2022). Trends of recreational water quality in Albania’s coastal during 2016–2020. Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, 57(4), 327–334. doi:10.1080/10934529.2022.2075653.

Pappou, S., Dardavila, M. M., Savvidou, M. G., Louli, V., Magoulas, K., & Voutsas, E. (2022). Extraction of Bioactive Compounds from Ulva lactuca. Applied Sciences (Switzerland), 12(4), 2117. doi:10.3390/app12042117.

Zhou, S., Di Paolo, C., Wu, X., Shao, Y., Seiler, T. B., & Hollert, H. (2019). Optimization of screening-level risk assessment and priority selection of emerging pollutants – The case of pharmaceuticals in European surface waters. Environment International, 128, 1–10. doi:10.1016/j.envint.2019.04.034.

HSE. (2023). BPR active substance lists for GB and NI. Health and Safety Executive, London, United Kingdom. Available online: https://www.hse.gov.uk/biocides/uk-list-active-substances.htm. (accessed on May 2023).

Abd El-Ghany, N. A., Elella, M. H. A., Abdallah, H. M., Mostafa, M. S., & Samy, M. (2023). Recent Advances in Various Starch Formulation for Wastewater Purification via Adsorption Technique: A Review. Journal of Polymers and the Environment, 31(7), 2792–2825. doi:10.1007/s10924-023-02798-x.

Bexfield, L. M., Toccalino, P. L., Belitz, K., Foreman, W. T., & Furlong, E. T. (2019). Hormones and Pharmaceuticals in Groundwater Used As a Source of Drinking Water across the United States. Environmental Science and Technology, 53(6), 2950–2960. doi:10.1021/acs.est.8b05592.

Malollari, I., Lajqi, V., Bazini, E., & Llupa, J. Radiation and photocatalytic removing of some pharmaceuticals discharged with hospital wastewater. UBT International Conference, Lipjan, Kosovo. doi:10.33107/ubt-ic.2022.313

Rahhou, A., Layachi, M., Akodad, M., El Ouamari, N., Rezzoum, N. E., Skalli, A., Oudra, B., El Bakali, M., Kolar, M., Imperl, J., Petrova, P., Moumen, A., & Baghour, M. (2023). The Bioremediation Potential of Ulva lactuca (Chlorophyta) Causing Green Tide in Marchica Lagoon (NE Morocco, Mediterranean Sea): Biomass, Heavy Metals, and Health Risk Assessment. Water (Switzerland), 15(7), 15. doi:10.3390/w15071310.

Samal, K., Mahapatra, S., & Hibzur Ali, M. (2022). Pharmaceutical wastewater as Emerging Contaminants (EC): Treatment technologies, impact on environment and human health. Energy Nexus, 6, 2772–4271. doi:10.1016/j.nexus.2022.100076.

Samineni, R., Chimakurthy, J., & Konidala, S. (2022). Emerging Role of Biopharmaceutical Classification and Biopharmaceutical Drug Disposition System in Dosage form Development: A Systematic Review. Turkish Journal of Pharmaceutical Sciences, 19(6), 706–713. doi:10.4274/tjps.galenos.2021.73554.

Nassiri Koopaei, N., & Abdollahi, M. (2017). Health risks associated with the pharmaceuticals in wastewater. DARU, Journal of Pharmaceutical Sciences, 25(1). doi:10.1186/s40199-017-0176-y.

Alagan, V., Valsala, R., & Rajesh, K. (2017). Bioactive Chemical Constituent Analysis, in vitro Antioxidant and Antimicrobial Activity of Whole Plant Methanol Extracts of Ulva Lactuca Linn. British Journal of Pharmaceutical Research, 15(1), 1–14. doi:10.9734/bjpr/2017/31818.

Fatta, D., Achilleos, A., Nikolaou, A., & Meriç, S. (2007). Analytical methods for tracing pharmaceutical residues in water and wastewater. TrAC - Trends in Analytical Chemistry, 26(6), 515–533. doi:10.1016/j.trac.2007.02.001.

Nieto-Juárez, J. I., Torres-Palma, R. A., Botero-Coy, A. M., & Hernández, F. (2021). Pharmaceuticals and environmental risk assessment in municipal wastewater treatment plants and rivers from Peru. Environment International, 155, 0160–4120. doi:10.1016/j.envint.2021.106674.

Leston, S., Rosa, J., Vila Pouca, A. S., Barbosa, J., Pardal, M. A., Ramos, F., & Freitas, A. (2023). Assessing pharmaceuticals in the green seaweed Ulva Lactuca through a multi-residue UHPLC-ToF-MS strategy. Marine Pollution Bulletin, 193. doi:10.1016/j.marpolbul.2023.115266.

Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989). Electrospray ionization for mass spectrometry of large biomolecules. Science, 246(4926), 64–71. doi:10.1126/science.2675315.

Belden, J. (2020). Introduction to ecotoxicology. An Introduction to Interdisciplinary Toxicology: From Molecules to Man, 381-393. doi:10.1016/B978-0-12-813602-7.00028-4.

Pitt, J. J. (2009). Principles and applications of liquid chromatography-mass spectrometry in clinical biochemistry. The Clinical Biochemist Reviews, 30(1), 19–34.

Munjanja, B. K. (2017). Liquid Chromatography Mass Spectrometry (LC-MS). Multiresidue Methods for the Analysis of Pesticide Residues in Food, 197-234.

Leyva-Morales, J. B., Valdez-Torres, J. B., Bastidas-Bastidas, P. J., & Betancourt-Lozano, M. (2015). Validation and Application of a Multi-residue Method, Using Accelerated Solvent Extraction Followed by Gas Chromatography, for Pesticides Quantification in Soil. Journal of Chromatographic Science, 53(10), 1623–1630. doi:10.1093/chromsci/bmv063.

Kiljanek, T., Niewiadowska, A., Semeniuk, S., Gaweł, M., Borzęcka, M., & Posyniak, A. (2016). Multi-residue method for the determination of pesticides and pesticide metabolites in honeybees by liquid and gas chromatography coupled with tandem mass spectrometry—Honeybee poisoning incidents. Journal of Chromatography A, 1435, 100–114. doi:10.1016/j.chroma.2016.01.045.

Paijens, C., Frère, B., Caupos, E., Moilleron, R., & Bressy, A. (2020). Determination of 18 Biocides in Both the Dissolved and Particulate Fractions of Urban and Surface Waters by HPLC-MS/MS. Water, Air, and Soil Pollution, 231(5), 231 210. doi:10.1007/s11270-020-04546-6.

Newman, S. P. (2022). Fine Particle Fraction: The Good and the Bad. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 35(1), 2–10. doi:10.1089/jamp.2021.29056.spn.

Vashist, S. K., & Luong, J. H. (2018). Handbook of immunoassay technologies: approaches, performances, and applications, Cambridge, Massachusetts, United States.

Rathod, R. H., Chaudhari, S. R., Patil, A. S., & Shirkhedkar, A. A. (2019). Ultra-high performance liquid chromatography-MS/MS (UHPLC-MS/MS) in practice: analysis of drugs and pharmaceutical formulations. Future Journal of Pharmaceutical Sciences, 5(1), 6. doi:10.1186/s43094-019-0007-8.

Hejna, M., Kapuścińska, D., & Aksmann, A. (2022). Pharmaceuticals in the Aquatic Environment: A Review on Eco-Toxicology and the Remediation Potential of Algae. International Journal of Environmental Research and Public Health, 19(13), 7717. doi:10.3390/ijerph19137717.

Gadipelly, C., Pérez-González, A., Yadav, G. D., Ortiz, I., Ibáñez, R., Rathod, V. K., & Marathe, K. V. (2014). Pharmaceutical industry wastewater: review of the technologies for water treatment and reuse. Industrial & Engineering Chemistry Research, 53(29), 11571-11592. doi:10.1021/ie501210j.

Verlicchi, P., & Grillini, V. (2020). Surfacewater and groundwater quality in South Africa and mozambique-analysis of the most critical pollutants for drinking purposes and challenges in water treatment selection. Water (Switzerland), 12(1), 305. doi:10.3390/w12010305.

Terefe Gemeda, F., Diriba Guta, D., Senbeta Wakjira, F., & Gebresenbet, G. (2020). Physicochemical characterization of effluents from industries in Sabata town of Ethiopia. Heliyon, 6(8), 2405–8440. doi:10.1016/j.heliyon.2020.e04624.

Nishu, & Kumar, S. (2023). Smart and innovative nanotechnology applications for water purification. Hybrid Advances, 3, 100044. doi:10.1016/j.hybadv.2023.100044.

Arora, B., & Attri, P. (2020). Carbon nanotubes (CNTs): A potential nanomaterial for water purification. Journal of Composites Science, 4(3), 135. doi:10.3390/jcs4030135.

Koul, B., Bhat, N., Abubakar, M., Mishra, M., Arukha, A. P., & Yadav, D. (2022). Application of Natural Coagulants in Water Treatment: A Sustainable Alternative to Chemicals. Water (Switzerland), 14(22). doi:10.3390/w14223751.

Weforum. (2023). Pharmaceuticals are present in almost all the world's rivers, study finds. World Economic Forum, Cologny, Switzerland. Available online: https://weforum.org/agenda/2022/02/pharmaceutical-pollution-health-drugs-rivers/ (accessed on May 2023).

Konstas, P. S., Kosma, C., Konstantinou, I., & Albanis, T. (2019). Photocatalytic treatment of pharmaceuticals in real hospital wastewaters for effluent quality amelioration. Water (Switzerland), 11(10), 2165. doi:10.3390/w11102165.


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DOI: 10.28991/HEF-2023-04-03-03

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